Human DNA Polymerase i: Wrong for the Right Reasons
نویسندگان
چکیده
منابع مشابه
Human DNA polymerase iota: wrong for the right reasons.
In a recent collaborative study, Thomas A. Kunkel, director of the NIEHS Environmental Biology Program, NIEHS deputy director Samuel H. Wilson, and Roger Woodgate, an investigator at the National Institute of Child Health and Human Development, report novel findings about DNA repair and genome stability in humans. Woodgate's laboratory recently discovered and purified polymerase iota (pol ι), o...
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DNA polymerase (pol) β is a model polymerase involved in gap-filling DNA synthesis utilizing two metals to facilitate nucleotidyl transfer. Previous structural studies have trapped catalytic intermediates by utilizing substrate analogs (dideoxy-terminated primer or nonhydrolysable incoming nucleotide). To identify additional intermediates during catalysis, we now employ natural substrates (corr...
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DNA polymerase 6 was purified from human placenta and its polymerase catalytic subunit identified as a 125-kDa polypeptide by activity staining. This 125kDa form of DNA polymerase 6 resembles that reported from calf thymus (Lee, M. Y. W. T., Tan, C.-K., Downey, K. M., and So, A. G . (1984) Biochemistry 23, 1906-1913) and differs in molecular properties from a previously described form isolated ...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 2001
ISSN: 0091-6765
DOI: 10.2307/3454770